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Norovirus in the United States: A Comprehensive Review


Norovirus, often referred to as the "stomach flu" or "stomach bug," is a highly contagious virus that causes acute gastroenteritis, characterized by inflammation of the stomach and intestines. While it can affect individuals of all ages, young children, older adults, and those with weakened immune systems are particularly vulnerable. This comprehensive review delves into the burden of norovirus in the United States, exploring its symptoms, transmission, prevention strategies, treatment options, and public health implications.  

Burden of Norovirus in the United States

Norovirus is the most common cause of acute gastroenteritis in the United States, leading to a significant public health burden. Each year, norovirus is responsible for:  

  • 19-21 million cases of acute gastroenteritis, resulting in vomiting and diarrhea  
  • 2.3 million outpatient visits  
  • 450,000 emergency department visits, primarily among young children  
  • 109,000 hospitalizations  
  • 900 deaths, mostly among adults 65 years and older  

These figures underscore the substantial impact of norovirus on healthcare resources and the overall well-being of the population. Young children are more likely to have an outpatient or emergency department visit, while older adults are most at risk of hospitalization and death due to dehydration from vomiting and diarrhea. Individuals with weakened immune systems are also more susceptible to severe infections.  

Symptoms of Norovirus Infection

Norovirus infection typically manifests with a sudden onset of symptoms, including:

  • Most common symptoms:
    • Diarrhea  
    • Vomiting  
    • Nausea  
    • Stomach pain  
  • Other symptoms:
    • Fever  
    • Headache  
    • Body aches  

These symptoms generally appear within 12 to 48 hours after exposure to the virus and last for 1 to 3 days. While most people recover completely within a few days, some, particularly the very young, the elderly, and those with weakened immune systems, may experience dehydration and require medical attention. Individuals with norovirus illness can still spread the virus for at least 2 days (48 hours) after symptoms stop.  

Transmission of Norovirus

Norovirus is highly contagious and spreads easily through various routes:

  • Person-to-person contact: Direct contact with an infected individual, such as caring for them or sharing food or utensils.  
  • Contaminated food or water: Consuming food or drinks that have been contaminated with norovirus. This can occur during food preparation or through contact with contaminated surfaces.  
  • Contaminated surfaces: Touching surfaces or objects contaminated with norovirus and then touching your mouth or eating without washing your hands.  

The virus is found in the stool and vomit of infected individuals. It is extremely transmissible, as it only takes a few viral particles to make someone sick.  

Prevention of Norovirus Infection

Preventing norovirus infection requires a multi-faceted approach:

  • Hand hygiene: Frequent and thorough handwashing with soap and water for at least 20 seconds is crucial, especially after using the toilet, changing diapers, and before handling food or eating.  
  • Food safety: Proper food handling practices, including washing fruits and vegetables, cooking shellfish thoroughly, and avoiding contaminated food or water, are essential.  
  • Disinfection: Cleaning and disinfecting contaminated surfaces with a bleach-based cleaner or EPA-registered disinfectant is important to prevent the spread of the virus.  
  • Isolation: Individuals with norovirus illness should stay home from work or school for at least 2 days (48 hours) after symptoms stop to prevent further transmission.  

Treatment of Norovirus Infection

There is no specific antiviral treatment for norovirus infection. Antibiotic drugs will not help treat norovirus infections because they fight bacteria, not viruses. Management focuses on alleviating symptoms and preventing dehydration:  

  • Fluid replacement: Drinking plenty of fluids, such as oral rehydration solutions, is crucial to replace fluids lost through vomiting and diarrhea.  
  • Rest: Getting adequate rest can help the body recover.  
  • Dietary modifications: Eating bland, easy-to-digest foods can help reduce nausea and vomiting.  
  • Over-the-counter medications: Over-the-counter anti-diarrheal medications and medications to reduce nausea may be used, but it's essential to consult a healthcare provider before using them, especially for children.  

Public Health Impact of Norovirus

Norovirus has a significant impact on public health due to its high transmissibility and potential for outbreaks. The virus can spread rapidly in closed settings, such as schools, healthcare facilities, and cruise ships. Outbreaks can lead to disruptions in daily activities, economic losses, and strain on healthcare resources. Each year, foodborne norovirus illness in the United States costs about $2 billion, mainly due to lost productivity.

Globally, norovirus causes about 1 in every 5 cases of acute gastroenteritis that leads to diarrhea and vomiting. It is estimated to cost $60 billion worldwide due to healthcare costs and lost productivity.  

Controlling norovirus outbreaks presents a significant challenge due to the virus's high transmissibility, low infectious dose, and environmental persistence. Public health surveillance plays a crucial role in monitoring norovirus activity, identifying outbreaks, and implementing control measures. Future interventions, such as vaccine development, are being explored to further reduce the impact of norovirus.

Recent outbreaks highlight the ongoing public health concern posed by norovirus. In the Northeast United States, a surge in norovirus cases was reported, with the three-week average of positive tests exceeding 10% since mid-December 2023. Other areas of the US also reported increases in positive tests. Additionally, outbreaks on cruise ships, such as the Queen Victoria and Celebrity Constellation, have been investigated by the Centers for Disease Control and Prevention (CDC).

Norovirus remains a significant public health challenge in the United States and globally. Its high transmissibility, low infectious dose, and ability to cause outbreaks contribute to its substantial impact on healthcare resources and the economy. While most individuals recover without complications, vulnerable populations are at risk of severe illness and long-term effects.

Healthcare professionals and public health officials must remain vigilant in promoting awareness, implementing preventive measures, and ensuring proper management of norovirus infections. Continued research is needed to develop effective prevention strategies, such as vaccines, and to improve our understanding of the virus's epidemiology and impact. By working together, we can minimize the burden of norovirus and protect the health of our communities.


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